знания и навыки

учебная и научная литература

научно-популярная литература

медицина / здравоохранение

зарубежная образовательная литература

The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response, the difficulty in directing oligonucleotides to particular target tissues and cells, the need for parenteral administration, and doubts concerning the mechanism of action (especially problems associated with non-specific binding to proteins) and long-term effects.

Oligonucleotides as Therapeutic Agents

This book contains chapters by some of the leading figures in the field of evolutionary psychology. The latest data are presented on evolutionary theories in perception, information, various aspects of social behaviour, language, learning and aggression. A common theme running through the printed discussions in this book is the important problem of how we can develop and test rigorous characterizations of evolved mental adaptations.

книги по психологии

о бизнесе популярно

общая психология

просто о бизнесе

Characterizing Human Psychological Adaptations

Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.

науки о Земле

география

детская познавательная и развивающая литература

развитие кругозора

эрудиция

интересные факты

Азия

страноведение

иллюстрированное издание

занимательная география

Telomeres and Telomerase

Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.

религия и духовная литература

религии / верования / культы

психология, мотивация

Gap Junction-Mediated Intercellular Signalling in Health and Disease

The mapping of human genes is proceeding rapidly. Genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. Variation in the Human Genome discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders such as cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour development susceptibility are used to illustrate this genetic variability and mechanisms of gene mutation and evolution.

современная русская литература

Variation in the Human Genome

This new work contains the first integrated discussion of the role of olfaction in mosquito-host interactions. It covers the practical applications of this knowledge in attempting to control malaria as a problem for world health. The volume begins with a general overview of mosquito life cycle styles and how odour-mediated host location fits into the repertoire of behaviours that a specific species may exhibit. Certain aspects of insect olfaction and its underlying physiological mechanisms are incorporated within the book.

Olfaction in Mosquito-Host Interactions

'Homology' as a concept became increasingly elusive during the course of the 20th century. The central debates and controversies concern both fundamental definitions and the nature of the criteria by which homology is judged. Attempts to move away from comparative morphology to ideas based on developmental pathways have tended to founder on the fact that developmental pathways evolve and that similar cells or tissues or structures in animals will often have different developmental origins. The use of information about conserved molecules in seemingly conserved developmental processes has also proven controversial. In molecular biology, the use of the term 'homology' has given rise to more debate, although here the issue seems to involve primarily the criteria for assessing whether parts of genes are the same because of shared descent or for other reasons. The contributions to the book explore these topics systematically. There are chapters on the historical development of the concept of homology and its use in population studies. Other chapters deal with issues of homology in morphological and developmental studies, in behavioural studies, and especially in studies at the level of molecular genetics.

Homology

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.

эзотерика / оккультизм

медицина

здоровье

Epigenetics

Asthma is a growing health problem throughout the developed world. This volume presents a critical review of all the possible factors for this rising trend and includes research that has not yet been published in the scientific literature. Discusses the basic biology of asthma and addresses genetic influences. Surveys the epidemiological evidence for the worldwide trends in morbidity and mortality.

биографии и мемуары

политические лидеры

Китай

коммунизм

The Rising Trends in Asthma

Microbial responses to acidic and alkaline pH are important in many areas of bacteriology. For example, the mechanisms of resistance to acidic pH are important in the understanding of the passage of human pathogens through the acid of the stomach; and an understanding of microbial degradation of alkaline industrial waste is important for the environment. Bringing together contributions from an international and interdisciplinary group of experts working on the many aspects of bacterial cellular responses to pH, this stimulating volume draws together new and innovative work in this area. It delineates both similarities and differences between mechanisms of tolerance and response, providing readers with an invaluable resource on the subject.

историческая литература

русская классика

ЛитРес: чтец

серьезное чтение

об истории серьезно

Bacterial Responses to pH

Gramicidin channels have been studied intensively for more than 25 years. They serve as model transport systems for large protein ion channels, since it is difficult to glean high-resolution structural information on the latter. This book includes contributions from virtually all the major scientists studying gramicidin channels and is the only compilation of work in this field. It discusses crystallographic, spectroscopic, electrophysiological and computational studies, especially in the light of the recent availability of high-resolution structural data, and it compares these with insights derived from larger systems. As well as drawing together much new and exciting work in this field, it provides pointers to promising new research directions.

пьесы и драматургия

пьесы, драматургия

Gramicidin and Related Ion Channel-Forming Peptides

This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.

Somatostatin and Its Receptors

T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.

T Cell Subsets in Infectious and Autoimmune Diseases

This volume examines obesity disorders which can lead to diabetes, hypertension and hyperlipidaemia. It offers an interdisciplinary and international look at all aspects of the origins, consequences and treatment of obesity.

юмористическая литература

юмор и сатира

смешные рассказы

ироничная проза

памфлеты

сарказм

The Origins and Consequences of Obesity

This up-to-the-minute account examines how radionuclides affect human health. It explores how radionuclides travel through various food chains and how they are transported throughout the terrestrial and aquatic environments.

зарубежная психология

саморазвитие / личностный рост

зарубежная эзотерическая литература

духовная мудрость

тайны и загадки бытия

духовные наставления

притчи

самопознание

удивительные истории

эзотерические учения

осознанность

Health Impacts of Large Releases of Radionuclides

The molecular mechanisms and protein species associated with the mineralization of mature dental enamel are active areas of research. This book focuses on specific areas of research including the structural chemistry, protein biochemistry and genetics of enamel development.

стихи и поэзия

cтихи, поэзия

Dental Enamel

This book details the rapidly advancing research on the development of the cerebral cortex. Topics covered include: new physiological data showing patterns in developing cortical organization; abnormalities of cortical development associated with psychiatric disorders; and research on cell identity and regionalization of the cortex.

Development of the Cerebral Cortex

Без серии

Gail Cardew