Фармакология

Книга в сжатой и доступной форме содержит информацию по сущности статистических методов обработки результатов исследований в медицине и фармации, особенности их применения рассмотрены на конкретных задачах и примерах. Базовые понятиятия и принципы
статистической обработки данных позволят избежать ошибок в выборе статистических методов при применении различных статистических программных пакетов и в изложении результатов статистического анализа.
Поиск информации облегчиат предметный указатель и глоссарий понятий учебных дисциплин. Изложение теории проиллюстрировано примерами из разнообразных областей медицины и фармации, которые должны стимулировать читателя к реальному п применению методов
статистического анализа данных для решения как научных так и пх, так и практических задач. В разделы по темам включены вопросы для самоконтроля и тестовые задания для проверки итогового уровня усвоения учебного материала.
Книга может быть полезна студентам,курсантам и слушателям, адъюнктам и аспирантам, врачам и фармацевтам, научным сотрудникам, а также обучающимся на факультетах подготовки врачей и провизоров, участвующим в работе научных кружков на соответствующих
кафедрах медицинских и фармацевтических ВУЗов области образования "Здравоохранение и медицинские науки".

В издании представлен материал по актуальным вопросам общей рецептуры, знание которого необходимо в клинической практике любого врача. Соответствует актуальным требованиям Федерального государственного образовательного стандарта высшего образования. Предназначено для студентов медицинских факультетов, врачей общей практики (семейных врачей) и врачей других специальностей.

Nicotine is considered to be the main agent in the maintenance of the tobacco smoking habit and is largely responsible for the behavioral and physiological responses to the inhalation of tobacco smoke. This work presents advances made in the elucidation of the action of nicotine in the body–essential information for developing treatments to help people give up smoking. The book reviews the progress made in identifying nicotinic acetylcholine receptors in the brain, using the techniques of molecular biology to characterize receptors and investigate the functional differences between receptors composed of different types of subunits. Sex-specific differences in the response to nicotine, the effects of nicotine on locomotor activity, and its still-debated influence on cognitive performance are considered. The book also examines the habit-forming role of nicotine, the development of tolerance to nicotine, and the less clearly understood phenomenon of withdrawal. Also discusses some potential therapeutic strategies.

Interest in the field of pharmacovigilance has grown rapidly in recent years with the possible toxicity of a drug becoming as much a focus of clinical trials as its benefits. This key text is a definitive resource for professionals working within pharmacovigilance. Written by leading professionals in the field, its clear structure, covers all the important aspects of the subject including:– * Legal aspects * Drug regulatory requirements * Methods of signal generation * Reporting schemes * Pharmacovigilance in selected system-organ classes * Future directions This comprehensive book should be in all pharmacovigilance departments, regional pharmacovigilance centres and regulatory authorities. It is an unparalleled source of information and reference for all researchers in pharmacovigilance, pharmaceutical practice and medicine.

Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis. Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances. Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

Written by an international team of outstanding editors and contributors, Pharmacovigilance, 2nd Edition is the definitive text on this important subject. The new edition has been completely revised and updated to include the latest theoretical and practical aspects of pharmacovigilance including legal issues, drug regulatory requirements, methods of signal generation, reporting schemes and pharmacovigilance in selected system-organ classes. . The editors and contributors are of excellent standing within the pharmacovigilance community The text provides exemplary coverage of all the relevant issues The definitive book on the subject

This timely and original handbook paves the way to success in plant-based drug development, systematically addressing the issues facing a pharmaceutical scientist who wants to turn a plant compound into a safe and effective drug. Plant pharmacologists from around the world demonstrate the potentials and pitfalls involved, with many of the studies and experiments reported here published for the first time. The result is a valuable source of information unavailable elsewhere.

Well received in its first edition, Survival Analysis: A Practical Approach is completely revised to provide an accessible and practical guide to survival analysis techniques in diverse environments. Illustrated with many authentic examples, the book introduces basic statistical concepts and methods to construct survival curves, later developing them to encompass more specialised and complex models. During the years since the first edition there have been several new topics that have come to the fore and many new applications. Parallel developments in computer software programmes, used to implement these methodologies, are relied upon throughout the text to bring it up to date.

Pharmaceutical Ethics is an important text, which aims to provide the ethical guidelines much needed by the pharmaceutical industry. By focusing on many of the central issues such as the ethical aspects of clinical trials, informed consent, physician or patient choice and pharmaceutical advertising, this text will provide very good coverage of an area which perhaps still lacks coherent instruction. * Covers ethical issues involved in the testing and use of pharmaceuticals on human beings * Investigates issues such as whether choice of drug should lie with the physician or the patient * Looks at a wide variety of subjects connected with pharmaceutical ethics. * Focuses specifically on the issues surrounding the pharmaceutical industry, not medicine in general. * Fulfils an important need in the Pharmaceutical Industry.