This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

научно-популярная литература

зарубежная образовательная литература

The hERG Cardiac Potassium Channel

The Limits of Reductionism in Biology

Molecular Mechanisms Influencing Aggressive Behaviours

Fatty Acid and Lipotoxicity in Obesity and Diabetes

Antimicrobial Peptides

Epithelial Anion Transport in Health and Disease

Biology of IGF-1

Acetaldehyde-Related Pathology

Environmental Statistics

Development of the Cardiac Conduction System

Rhodopsins and Phototransduction