Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

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знания и навыки

Voltage-Gated Ion Channels as Drug Targets

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Fragment-based Drug Discovery. Lessons and Outlook

Pharmacokinetics and Metabolism in Drug Design

In vivo Models for Drug Discovery

Reactive Drug Metabolites

Scaffold Hopping in Medicinal Chemistry

Data Mining in Drug Discovery

Drug Metabolism Prediction