This new book explores clinical information in the tissue transplantation field and acts as a comprehensive learning tool to comply with regulatory requirements. Broad in scope, coverage includes all the traditionally transplanted tissues and moves into more complex areas of tissue grafting and the assisted reproduction fields. This useful text focuses on the potential for disease transmission, wa…
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for…
Mathematical problems such as graph theory problems are of increasing importance for the analysis of modelling data in biomedical research such as in systems biology, neuronal network modelling etc. This book follows a new approach of including graph theory from a mathematical perspective with specific applications of graph theory in biomedical and computational sciences. The book is written by re…
This practical step-by-step guide to performing GI endoscopy safely and effectively in children covers the use of endoscopy as both a diagnostic and a therapeutic modality. Now with an entirely new section focusing on advanced endoscopic techniques, such as such as pancreatic cysto-gastrostomy, confocal endo microscopy, and single balloon enteroscopy, the new edition gives trainees and practitione…
This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's d…
Prevention is the first line of defence in the fight against infection. As antibiotics and other antimicrobials encounter increasing reports of microbial resistance, the field of decontamination science is undergoing a major revival. A Practical Guide to Decontamination in Healthcare is a comprehensive training manual, providing practical guidance on all aspects of decontamination including: micro…
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the «bench to bedside» translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on th…
Soft tissue tumors (STTs) are frequently misdiagnosed in inexperienced hands. Having diagnosed and treated hundreds of patients with these difficult tumors in the last few years, Institut Curie physicians have collected core data contributing to breakthrough research into the morphological, biological, and molecular aspects of soft tissue tumors, resulting in valuable translational and clinical ap…
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. …
Dedicated to dealing with a challenging disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients. – Latest publication in a fast-moving area of keen clinical interest – Authored by leading international authorities – Builds on success of a respected first edition – Incorporates new data on latest imaging te…
In this pathbreaking volume, a multidisciplinary team of international experts puts catheter–based treatment techniques in context by exploring the pathobiology of specific diseases alongside a discussion of imaging tools and functional tests, and a comparison to alternative treatment approaches provided by cardiovascular surgery. This comprehensive overview of interventional cardiology: Explains …
In this pathbreaking volume, a multidisciplinary team of international experts puts catheter–based treatment techniques in context by exploring the pathobiology of specific diseases alongside a discussion of imaging tools and functional tests, and a comparison to alternative treatment approaches provided by cardiovascular surgery. This comprehensive overview of interventional cardiology: Explains …
In this pathbreaking volume, a multidisciplinary team of international experts puts catheter–based treatment techniques in context by exploring the pathobiology of specific diseases alongside a discussion of imaging tools and functional tests, and a comparison to alternative treatment approaches provided by cardiovascular surgery. This comprehensive overview of interventional cardiology: Explains …
In this pathbreaking volume, a multidisciplinary team of international experts puts catheter–based treatment techniques in context by exploring the pathobiology of specific diseases alongside a discussion of imaging tools and functional tests, and a comparison to alternative treatment approaches provided by cardiovascular surgery. This comprehensive overview of interventional cardiology: Explains …