Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function – from the molecular mechanism of…
This mini-encyclopedia contains more than 1,500 alphabetical entries from the entire field of peptide science in one handy volume, as well as the technical terms, acronyms and concepts used in peptide chemistry. It also features the complete sequence of more than 800 peptides, numerous illustrations and numerous cross-references. Areas covered include: – biological peptides and small proteins – pe…
Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enan…
The concepts, applications, and practical issues of Quality by Design Quality by Design (QbD) is a new framework currently being implemented by the FDA, as well as EU and Japanese regulatory agencies, to ensure better understanding of the process so as to yield a consistent and high-quality pharmaceutical product. QbD breaks from past approaches in assuming that drug quality cannot be tested into …
Medicines from Animal Cell Culture focuses on the use of animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration and the culture of stem cells…
Fruit flies are «little people with wings» goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which «define» humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling as…
This concise introduction to the fundamentals of biological treatment of wastewater describes how to model and integrate biological steps into industrial processes. The book first covers the chemical, physical and biological basics, including wastewater characteristics, microbial metabolism, determining stoichiometric equations for catabolism and anabolism, measurements of mass transfer and respir…
A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.
A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Gene flow is not unique to genetically modified (GM) crops, but the possibility of the spread of transgenic DNA to wild and domesticated relatives raises a new set of issues for scientists and policymakers to consider. Unfortunately, we are still too often unable to quantify the risks of ecological damage associated with gene flow. This is due partly to the huge breadth of knowledge required to as…
Evidence grows daily of the changing climate and its impact on plants and animals. Plant function is inextricably linked to climate and atmospheric carbon dioxide concentration. On the shortest and smallest scales, the climate affects the plant’s immediate environment and so directly influences physiological processes. At larger scales, the climate influences species distribution and community com…
Cell separation is an important process that occurs throughout the life cycle of a plant. It enables the radicle to emerge from the germinating seed, vascular tissue to differentiate, sculpturing of leaves and flowers to take place, pollen to be shed from the mature anther, fruit to soften, senescent and non-functional organs to be lost, and seeds to be shed. In addition to its intrinsic scientifi…
Presents readers with a user-friendly, non-technical introduction to statistics and the principles of plant and crop experimentation. Avoiding mathematical jargon, it explains how to plan and design an experiment, analyse results, interpret computer output and present findings. Using specific crop and plant case studies, this guide presents: * The reasoning behind each statistical method is explai…
Our knowledge of the circadian clock in plants has advanced considerably in recent years and we now have a clearer view of the biochemical processes making up its mechanism. Recent work provides insight into the central role played by the circadian system in the regulation of many aspects of metabolism. The multiple systems involved in photoreception have been determined, leading to an understandi…