The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and …
Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses. Medical Toxicology of Natural Substances finally gives you an easily accessible resource for vital toxicological information on foods, pla…
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in …
This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scatter…
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important refere…
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companio…
Nature provides us with an abundance of chemical potential. Presenting an overview of the use of bioresources in the 21st century, Introduction to Chemicals from Biomass covers resources, chemical composition of biomass, key factors affecting composition, utilization of wastes, extraction technologies, controlled pyrolysis, fermentation, platform molecules, and green chemical technologies for thei…
This extensively updated and revised version builds on the success of the first edition featuring new discoveries in powder technology, spraying techniques, new coatings applications and testing techniques for coatings – Many new spray techniques are considered that did not exist when the first edition was published! The book begins with coverage of materials used, pre-spray treatment, and the tec…
At a time when environmental concerns are increasing, it's important that chemical processes are as environmentally friendly as possible. This book outlines various methods for producing inorganic and organic solvents without the use of traditional solvents that can have detrimental effects on the environment. This is the first book to give extensive and exclusive coverage to the topic Includes im…
A guide to achieving business successes through statistical methods Statistical methods are a key ingredient in providing data-based guidance to research and development as well as to manufacturing. Understanding the concepts and specific steps involved in each statistical method is critical for achieving consistent and on-target performance. Written by a recognized educator in the field, Statisti…
Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and pur…
This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment and management of bacterial infec…
A Complete overview of theory, selection, design, operation, and maintenance This text offers a thorough overview of the operating characteristics, efficiencies, design features, troubleshooting, and maintenance of dynamic and positive displacement process gas compressors. The author examines a wide spectrum of compressors used in heavy process industries, with an emphasis on improving reliability…
Radicals and radical ions are important intermediates with wide use in organic synthesis. The first book to concentrate on reagents for the creation and use of radicals and radical ions, this new volume in the Handbooks of Reagents for Organic Synthesis series compiles articles taken from the e-eros database, on reagents for use in radical and radical chemistry, to help the chemist in the lab choo…
Familiarizes the student or an engineer new to process safety with the concept of process safety management Serves as a comprehensive reference for Process Safety topics for student chemical engineers and newly graduate engineers Acts as a reference material for either a stand-alone process safety course or as supplemental materials for existing curricula Includes the evaluation of SACHE courses f…