Cellular Aspects of HIV Infection provides a highly readable, detailed overview of the state of the art in modern HIV research at the cellular level. This volume brings together renowned experts who have provided concise, synthetic treatments of the biology of HIV infection. It presents these descriptions and analyses with particular attention to the techniques of flow cytometry that have allowed …
This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of re…
Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in t…
This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plant…
In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty ac…
This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also …
It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily «contaminated» with such foreign DNA, and mammals, like other organisms…
This book supplies an application-oriented introduction to molecular simulation techniques used to study a wide range of problems in molecular biology. Each chapter focuses in detail on one kind of application, including the scientific background, the appropriate methodology and the relationship to experimental results. The book contains many areas of interest to basic and industrial scientists, i…
Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Following an introduction…
The Almería Province of SE Spain, a semi-arid, tectonically active region, is the focus of a wide range of scientific teaching and research in the earth sciences by universities and associated bodies from around the world. This field guide provides an up-to-date and integrated approach to the geology and geomorphology of Almería Province, compiled by active scientific researchers in the region. Th…
The outcome of a symposium held in Fribourg, Switzerland, this book fulfils two aims. Firstly, it represents a collection of case-studies covering a wide range of basin types and tectonic and stratigraphic settings. Secondly, it highlights a number of specific themes such as the history of subsidence and its relation to orogenesis, the stratigraphic architecture of the basin fill and the petrograp…
This volume also discusses the computer modelling of carbonate cycles and sequence analysis. This will prove an invaluable text for senior undergraduate and postgraduate students in the earth sciences in general and will also be of value to the professional researcher. Carbonate platforms contains contributions from an international authorship and the volume has been edited by one of the most resp…