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In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty ac…
This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also …
It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily «contaminated» with such foreign DNA, and mammals, like other organisms…
This book supplies an application-oriented introduction to molecular simulation techniques used to study a wide range of problems in molecular biology. Each chapter focuses in detail on one kind of application, including the scientific background, the appropriate methodology and the relationship to experimental results. The book contains many areas of interest to basic and industrial scientists, i…
Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Following an introduction…
The Almería Province of SE Spain, a semi-arid, tectonically active region, is the focus of a wide range of scientific teaching and research in the earth sciences by universities and associated bodies from around the world. This field guide provides an up-to-date and integrated approach to the geology and geomorphology of Almería Province, compiled by active scientific researchers in the region. Th…
The outcome of a symposium held in Fribourg, Switzerland, this book fulfils two aims. Firstly, it represents a collection of case-studies covering a wide range of basin types and tectonic and stratigraphic settings. Secondly, it highlights a number of specific themes such as the history of subsidence and its relation to orogenesis, the stratigraphic architecture of the basin fill and the petrograp…
This volume also discusses the computer modelling of carbonate cycles and sequence analysis. This will prove an invaluable text for senior undergraduate and postgraduate students in the earth sciences in general and will also be of value to the professional researcher. Carbonate platforms contains contributions from an international authorship and the volume has been edited by one of the most resp…
This publication consists of papers delivered at an International Symposium of the International Association of Sedimentologists held at Beijing, Peoples' Republic of China in August, 1988. The theme of the symposium was sedimentology related to mineral deposits and incorporated meetings of three International Geological Correlation Programmes (IGCP) Projects; IGCP 219 on Comparative Lacustrine Se…
This book considers the deposition of sediments in different types of lakes and shows how changes in the lake environment can be interpreted from the sediment facies at the lake floor. Lakes are particularly sensitive to climate change and thus their sediments are accurate indicators of environmental change and palaeoclimate. This volume examines both ancient and modern lake deposits which is part…
The last decade of study of the shallow-marine boundary layer has arrived at a synthesis of sediment dynamic principles that can begin to be transferred from the time scales of the rock record (years to millenia). At the same time, the technology of petroleum exploration has lead to a fundamentally new way of examining the deposits of sedimentary basins. This book applies these insights to contine…
Stratigraphers and sedimentologists who are presently describing and interpreting the infill of sedimentary basins are generally agreed that it is difficult to disentangle the signatures of tectonic processes from those of climate and eustatic sea level change in the resultant rock succession. Until better criteria are developed to distinguish between the roles played by the major variables, it is…