Summarizes research encompassing all of the aspects required to understand, fabricate and integrate enzymatic fuel cells Contributions span the fields of bio-electrochemistry and biological fuel cell research Teaches the reader to optimize fuel cell performance to achieve long-term operation and realize commercial applicability Introduces the reader to the scientific aspects of bioelectrochemistry including electrical wiring of enzymes and charge transfer in enzyme fuel cell electrodes Covers unique engineering problems of enzyme fuel cells such as design and optimization