The Nobel Prize in Chemistry 2007 awarded to Gerhard Ertl for his groundbreaking studies in surface chemistry highlighted the importance of heterogeneous catalysis not only for modern chemical industry but also for environmental protection. Heterogeneous catalysis is seen as one of the key technologies which could solve the challenges associated with the increasing diversification of raw materials…
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important refere…
This extensively updated and revised version builds on the success of the first edition featuring new discoveries in powder technology, spraying techniques, new coatings applications and testing techniques for coatings – Many new spray techniques are considered that did not exist when the first edition was published! The book begins with coverage of materials used, pre-spray treatment, and the tec…
Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and pur…
Radicals and radical ions are important intermediates with wide use in organic synthesis. The first book to concentrate on reagents for the creation and use of radicals and radical ions, this new volume in the Handbooks of Reagents for Organic Synthesis series compiles articles taken from the e-eros database, on reagents for use in radical and radical chemistry, to help the chemist in the lab choo…
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing …
Mastering management skills is hard to achieve by newcomers starting their careers in the chemical industry. The message coming from there is that good chemists swiftly have to become good managers if they are to survive and progress in today's competitive climate. This book is designed to help guide younger R & D chemists to ways in which they can quickly evolve skills which are built around thre…
A guide for younger R&D chemists as to how they can quickly evolve skills built around three factors – people, knowledge and time. It covers the management of scientific personnel, management within a variety of R & D organizational structures, creating a climate of innovation, the management of projects including the time management and communication aspects of the job. As such, it teaches the vi…
Production-integrated environmental protection is synonymous with – reducing the amount of potential pollutants at source – reducing the consumption of resources and energy – recycling and utilization of residues and used products, and therefore a topic of considerable current interest. No chemical process exists that produces only the product desired. Therefore it is an important aim of the chemi…
Strategic planning is a critical subject, central to the success of any scientific and economical enterprise. Not only is the scientific knowledge of many persons needed, but also an assessment of what may occur in the future – which approach may be competitive, which option can be achieved, and how can this be accomplished. With a focus on the various ethical obligations to patients, animals and …
This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers bot…
Stratigraphers and sedimentologists who are presently describing and interpreting the infill of sedimentary basins are generally agreed that it is difficult to disentangle the signatures of tectonic processes from those of climate and eustatic sea level change in the resultant rock succession. Until better criteria are developed to distinguish between the roles played by the major variables, it is…
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new is…
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, c…
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, c…