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This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategie…
A valuable addition to the literature by any measure and surely will prove its merit in years to come. The new knowledge that arises with its help will be impressive and of great benefit to humankind. —From the Foreword by E. J. Corey, Nobel Prize Laureate An invaluable guide to name reactions and reagents for homologations Name Reactions for Homologations, Part I of Wiley's Comprehensive Name Rea…
This book provides an introduction to the underlying theory, fundamentals, and applications of EPR spectroscopy, as well as new developments in the area. Knowledge of the topics presented will allow the reader to interpret of a wide range of EPR spectra, as well as help them to apply EPR techniques to problem solving in a wide range of areas: organic, inorganic, biological, and analytical chemistr…
Multidimensional Liquid Chromatography (MDLC) is a very powerful separation technique for analyzing exceptionally complex samples in one step. This authoritative reference presents a number of recent contributions that help define the current art and science of MDLC. Topics covered include instrumentation, theory, methods development, and applications of MDLC in the life sciences and in industrial…
The Mediterranean region has been shaped by human activity and maintained by traditional practices of land use for centuries. This has affected the distribution of plants and the landscape, which can be considered as part of the European cultural landscape. This book details the rapid changes that have taken place in the vegetation of the Mediterranean in the last half-century, a period in which m…
GeoProc2008 collects the proceedings of the International Conference on Coupled T-H-M-C (thermal, hydraulic, mechanical, chemical) Processes in Geosystems.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
This handbook provides a straightforward introduction to spectroscopy, showing what it can do and how it does it, together with a clear, integrated and objective account of the wealth of information that can be derived from spectra. The sequence of chapters covers a wide range of the electromagnetic spectrum, and the physical processes involved, from nuclear phenomena to molecular rotation process…
T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.
T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.
The thoroughly revised and updated second edition of Ultra Wideband Signals and Systems in Communication Engineering features new standards, developments and applications. It addresses not only recent developments in UWB communication systems, but also related IEEE standards such as IEEE 802.15 wireless personal area network (WPAN). Examples and problems are included in each chapter to aid underst…
Advances in optical fibre based communications systems have played a crucial role in the development of the information highway. By offering a single mode oscillation and narrow spectral output, distributed feedback (DFB) semiconductor laser diodes offer excellent optical light sources as well as optical filters for fibre based communications and dense wavelength division multiplexing (DWDM) syste…
An Introduction to Aqueous Electrolyte Solutions is a comprehensive coverage of solution equilibria and properties of aqueous ionic solutions. Acid/base equilibria, ion pairing, complex formation, solubilities, reversible emf’s and experimental conductance studies are all illustrated by many worked examples. Theories of non-ideality leading to expressions for activity coefficients, conductance the…
Chemical thermodynamics considers the energy transformations which drive or which occur as a result of chemical reactions. It is a central discipline of chemistry and chemical engineering, allowing prediction of the direction of spontaneous chemical change and the position of chemical equilibrium in any reacting system. Being grounded in maths, it is often perceived as a difficult subject and many…
The use of light-emitting proteins for the detection of biomolecules provides fast and sensitive methods which overcome the disadvantages of radioactive labels and the high cost of fluorescent dyes. This reference work summarizes modern advanced techniques and their applications and includes practical examples of assays based on photoproteins. The book presents contemporary key topics like lumines…